Synthesis and analgesic activity of N-arylakyl-N [2- [1-pyrrolidinyl] cyclohexyl] propanamides
Bulletin of Faculty of Pharmacy-Cairo University. 1998; 36 (3): 33-8
en Inglés
| IMEMR
| ID: emr-47796
ABSTRACT
The objective of this study was investigate further the presence of structural or functional analogies between the arylacetamide U50488 [1] and fentanyl [3]. The synthesis and in vitro analgesic activity [hot-plate test] of N-benzyl, N-[2-phenylethyl], and N-[3-phenylpropyl] derivatives of trans-[ +/- ] -N-[2-[1-pyrrolidinyl] cyclohexyl] propanamide [5-7, respectively] were discussed. Attempts to synthesize N-phenyl derivative 4 were also discussed. The lack of significant analgesic activity of 5-7 indicated the stringent structural requirement for the N-methyl-N-arylacetamide group of the k-selective opioid trans-[ +/- ]-2-[3, 4-dichlorophenyl]-N-methyl- N-[2- [1-pyrrolidinyl] cyclohexyl] acetamide [U50488][1]
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Analgésicos
/
Acetamidas
Idioma:
Inglés
Revista:
Bull. Fac. Pharm.-Cairo Univ.
Año:
1998
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