Further evaluation of certain sulindac suspensions

ABSTRACT

Microscopical characteristics and crystal growth, chemical stability, accelerated stability and the effect of dilution on physical and chemical stability were studied. Stable suspensions of choice were pharmacologically evaluated regarding anti-inflammatory, analgesic, and antipyretic effects as well as ulcerogenesis using laboratory animals. Clinoril tablet, the only marketed sulindac product, was taken as standard for comparison. The deflocculated formula 3 [containing 0.5% w/v xanthan gum] and the flocculated formula c [containing 10% glycerin, 10% propylene glycol, and 40% sorbitol as density modifiers] were the most stable among the tested formulae. The pharmacological evaluation of both suspension formulae showed anti-inflammatory, analgesic and antipyretic effects comparable to those of clinoril tablets; while ulcerogenesis was less. The flocculated suspension was the least ulcerogenic. Moreover, it showed earlier anti-inflammatory, analgesic, and antipyretic responses reflecting faster absorption