Analgesic and anti-inflammatory activity of semecarpus anacardium linn

ABSTRACT

Semecarpus anacardium L. [fruit aqueous extract] exerted moderate analgesic activity as revealed in experiments on mice and rats. In the experiments utilizing the peak effect was noticed at 30 minutes after the administration of the drug which was highly significant [p<0.001]. At this time interval it was equivalent to acetaminophen in its activity. In the analgesic studies using rat, the peak effect was achieved after 60 minutes of the administration of the drug in highly significant [p<0.01]. In the inflammation studies the curative model showed better response on rats. In case of preventive effect the 1st [14.19%, p<0.001], and [20.0%, p<0.001] and 3rd [21.94%, p<0.001] hours after treatment the effect of Semecarpus anacardium L. was better than the Diclofenac sodium [DCF]. In the curative model, the inhibition of inflammation was better than acetylsalicylic acid [ASA] and Ibuprofen [IBP]. Treatment with Semecarpus anacardium L. causes the percent age of inhibitions after 1st [14.18,% p<0.01], 2nd [20.57%, p<0.001], 3rd [29.79%, p<0.001] and 4th [35.46%, p<0.001] hours. Semecarpus anacardium treated animals did not show any gastric irritation