Effect of alkali on metastatic calcification produced by hyper vitaminosis D

ABSTRACT

The effect of alkali [Sodium Bicarbonate] on metastatic calcification produced by Hypervitaminosis D [ergocalciferol] was studied in rats. Six organs e.g. kidneys, heart, lungs, stomach, aorta and liver of the rats were examined for evidence of calcification. Six out of ten rats receiving vitamin D alone and seven out of ten rats receiving vitamin D and sodium - bicarbonate in combination, showed clacification of various organs. There was no significant difference in the amount and distribution of calcification between the two groups, except in the lungs where calcification was more severe in the animals receiving alkali along with vitamin D