pharmaceutical study on topically applied tenoxicam gel

ABSTRACT

Tenoxicam transparent oil-water [TOW] gels were prepared using different oils; namely, isopropyl myristate, liquid paraffin, and myritol 318. The emulsifying agents used were Eumulgin B3, Cetiol HE, Brij 96, and Tween 80. The prepared gels were examined visually, microscopically and were photomicrographed. Conductivity, pH as well as rheological properties were determined. In vitro release studies, accelerated stability testing, and determination of anti-inflammatory activity were also performed. The results revealed that tenoxicam TOW gel prepared with liquid paraffin, Eumulgin B3, Cetiol HE combination and water [formula IV] was the most stable formula. It also affords reasonable pH, conductivity, rheological properties and in vitro drug release. The selected formula showed appreciable anti-inflammatory activity [determined by the Carrageenan induced rat paw edema] compared with a commercial piroxicam gel