Effect of long term therapy of some antiinflamatory agents on metabolic and functional characteristics of respiratory muscles in rats

ABSTRACT

This study utilized the metabolic differentiation paradigm of respiratory muscles which was related to the relative capacities of anaerobic and aerobic bioenergetic glycolytic and oxidative enzyme activities as a relative measure of these pathways. The results supported the deleterious effect of corticosteroids, indomethacin and garamycin on respiratory muscles through alterations in biochemical and metabolic functions of the muscles by different degrees and different ways. Also, it provided a scope on vitamin E and its important and vital role in protection against respiratory muscle damage produced by different drugs and by different mechanisms. These results were discussed