Synthesis and pharmacological evaluation of some new quinazoline- [1,2-C] quinazoline and 1,2,4-triazino [4,3-C] quinazoline analogs

ABSTRACT

Some new quinazolino [1,2-c] quinazolin-13-ones and 2,3,4,5-tetrahydro-2,5,-dioxo-1H-1,2,4 triazino [4,3-c] quinazolines were synthesized an characterized by both elemental and spectral analyses. Pharmacological evaluation of these erivatives showed that some viny1 derivatives of quinazolinoquinazolinone possess a significant hypnotic activity compared with phenobarbitone, whereas, other quinazolinoquinazolinones and trizinoquinazolins, showed mild non-narcotic analgesic activity compared with paracetamol