Intratympanic gentamicin in unilateral Meniere's Disease: Titration therapy

ABSTRACT

Twenty five patients disabled by episodic vertigo attacks of unilateral Meniere's disease were treated with administration of gentamicin intratympanically in a titration treatment protocol where one injection every two weeks was given, terminating the therapy when sufficient effect was observed as evidenced by the patient report or audiologically. Vertigo was completely eliminated in 72% with additional 20% of substantial control and only 8% limited control. Hearing was unchanged in 44%, improved in 32% and worse in 24% of patients. Intratympanic gentamicin titration therapy is safe, easily performed as an outpatient procedure with only topical anesthesia