Influence of gelucires and rhodopases on sustainment of in -domethacin via solid dispersions

ABSTRACT

Solid dispersions of indomethacin in different release retarding materials; namely, Gelucire 50/02 and Gelucire 50/13, Rhodopas M and Rhodopas H were prepared by fusion and coprecipitation methods, respectively. Solid dispersions were compressed into tablets where both physical parameters and dissolution were studied. The effect of various release retardants on anti-inflammatory characteristic of indomethacin adopting rat paw edema and ulcerogenicity on rat stomach from the most appropriate preparations reached were done. A satisfactory prolongation of drug dissolution from its tablets made with Gelucires was obtained from drug tablets containing 10% w/w of Gelucire 50/02. However, drug tablets prepared with 2.5% of the same polymer showed a shorter retardation time. The percentage of drug release was decreased by increasing the percentage of Gelucire 50/02. In contrast, the increasing Gelucire 50/13 concentration caused a remarkable increase in drug release from its tablets. On the other h and, indomethacin tablets prepared with Rhodopases M and H showed a remarkable protraction of the drug release. The greatest protraction was obtained with 6% Rhodopas H that was too excessive to attain a reasonable level