Microencapsulation of indomethacin using different polymers

ABSTRACT

Indomethacin microcapsules were prepared with three different polymers; namely, ethyl cellulose 100[EC], Eudragit RSPM [Eud] and sodium carboxymethylcellulose [Na CMC] using solvent-evaporation technique with the first two polymers and coacervation-phase separation by electrolyte addition technique with the latter. Kollidon K-25 was used as a channeling agent. All the prepared microcapsules were subjected to drug content determination, microscopical examination, particle size analysis and drug release studies. The anti- inflammatory characteristic adopting rat paw edema method and ulcerogenicity in terms of ulcer index on rat stomach of indomethacin from the most appropriate preparation reached were studied