Impairment of some renal and hepatic functions implicated in cerebrovascular stroke

ABSTRACT

The present study was conducted on 52 patients with recent onset cerebrovascular stroke [within 24 hours of onset] and 25 age and sex matched healthy control subjects. The study showed significantly higher levels of serum creatinine, blood urea and total serum bilirubin and lower level of serum albumin in stroke patients when compared with controls. While, this was not true for total proteins, AST, ALT and alkaline phosphatase, where the difference was not significant. Furthermore, significant differences reported beforeh and, almost, persisted between the three stroke subtypes and control. In general, a significant positive correlation was found between serum creatinine as well as blood urea nitrogen and diastolic blood pressure, while, a negative correlation was observed between serum albumin and glycosylated hemoglobin. These findings may be attributed, at least in part, to general vascular disease in such age group. In addition, in this country, endemic diseases known to have compromise on both liver and kidneys may contribute to such findings: