Inflammatory parameters implicated in cerebrovascular stroke

ABSTRACT

This study was conducted on 52 patients with recent onset cerebrovascular stroke and 25 age and sex matched healthy control subjects. It was aiming to assess some inflammatory parameters in recent stroke patients and analyze its relation to the traditional risk factors of stroke. A significant increase has been found in almost all traditional risk factors as well as inflammatory parameters in stroke patients and stroke subtypes as compared to control subjects. Some significant correlations have been found between traditional risk factors and inflammatory parameters in stroke patients as well as stroke subtypes but this was neither extensive nor consistent. Furthermore, no significant correlation was detected between different inflammatory parameters. Soluble tumor necrosis factor receptor one [STNFR1] was more sensitive and consistent than TNF in both stroke patients and subtypes and this was attributed to dilution in peripheral blood and the very unstable nature of TNF alpha or it may be explained by the fact that the effect of leukocyte activation and the release of some cytokines are more pronounced locally at the site of injury and inflammation