Vitreous / blood concentration ratio in drug overdoses an experimental study

ABSTRACT

Serum and vitreous concentrations in three drug overdoses [phenobarbitone,morphine and theophylline] were measured in albino rats after 1, 2, 4 and 12 hours of i.p. injection. Vitreous/blood ratio was determined for every drugoverdose. It was found that this ratio remained constant regardless of thetime passed since injection. The study demonstrated that vitreous is a cleanbiological fluid that can be used for the detection of drug overdose by EMIT and can predict the blood concentration of the drug as long as vitreous/bloodratio is known