Role of fish oil and vitamin c in protection against nephrotoxicity induced by vancomycin in albino rat

ABSTRACT

This study aimed to investigate the role of fish oil and vitamin C alone and in combination in renal protection from vancomycin induced nephrotoxicity. Forty adult male albino rats were used in this study and were divided into eight groups of five animals each. The duration of the experiment was ten days, then all the animals were sacrificed and blood samples were collected to investigate the renal functions [blood urea nitrogen and serum creatinine]. Lipid peroxidase activity in both plasma and renal tissue was also estimated. Both kidneys were removed and prepared for histological examination. The results showed that vitamin C induced significant improvement of vancomycin nephrotoxicity. On the other hand, fish oil induced less significant improvement. The maximum protection was observed following combination of both vitamin C and fish oil with vancomycin. This protective effect was obtained both biochemically and histologically