Vitamin E and C status in hemodialysis pateints of Shaikh Zayed hospital [Lahore]

ABSTRACT

Cardiovascular disease is the major cause of mortality in patients receiving haemodialysis for chronic renal failure. Increased lipid peroxidation and deplation of antioxidants may contribute to increased risk of atherosclerosis. The present study was carried out to see the predialysis level of vitamin C and vitamin E in ESRD [end stage renal disease] patients of Shaikh Zayed Hospital Lahore receiving regular heamodialysis, and also the immediate effect of dialysis on vitamin C and E levels. Fifty ESRD patients on heamodialysis and 15 healthy control subjects matched for age and sex were included in the study. Forty one patients and 12 controls were in the age range of more than 30 years. No significant difference was seen in the predialysis vitamin C level of patient and control, but the fall after dialysis was significant. No significant correlation could be elicited between the post dialysis fall of vitamin C level of 6 or more than 6 mg/l in patient with previous history of diabetes/hypertention, period of dialysis or frequency of dialysis. Predialysis vitamin E level of patient was significantly lower than control subjects, where as the level of vitamin e was lower in female than male patients. no significant fall of vitamin E level was seen after dialysis. No significance could be elicited between initial lower level of vitamin E, [less than 6 mg/l] and previous history of diabetes/hypertention, period of dialysis and frequency of dialysis