Endometriosis; efficacy and safety of decapeptyl [triptorelin] in its treatment

ABSTRACT

A prospective study was carried out during 1st September 1995 to 31 st August in private patients of Sir Ganga Ram Hospital, Lahore. The purpose was to study the safety and efficacy of decapeptyl in the treatment of endometriosis. Six women with proven endometriosis were treated with a delayed release preparation of the super active agonist D. Trp-6-LH-RH in biodegradable microcapsules, administered intra-muscularly at intervals of 30 days for a period of 6 months. All patients showed clinical improvement and reduction in stage and score of endometriosis. Hot flushes and dyspareunia were the main side effects. Resumption of menses occurred in all patients after the last injection. Results demonstrate that a long lasting, reversible hypogonadism can be induced in cyclic women by intramuscular injections of D. Trp-6-LH-RH microcapsules at monthly intervals. This simple and conventient treatment should be useful in treating endomentriosis