Susceptibility of clinically significant ocular isolates to lomefloxacin 0.3

ABSTRACT

Purpose: The main objective of this in vitro study was to assess the antibacterial activity of lomefloxacin against clinically significant bacterial isolates and to compare the efficacy of lomefloxacin with the antibiotics of common practice. Materials and A total of 100 clinically significant isolates from the conjunctival swab culture were used in this study. Blood and chocolate agar plates and thioglycolate broth were used as culture media. Chloramphenicol, Tobramycin, Gentamicin, Fucidic acid, Ampicillin, Ciprofloxacin, Erythromycin, Tetramycin and Vancomycin antibiotics were used as comparison drugs versus lomefloxacin 0.3%. Results Sixty% of the 100 cases had acute bacterial conjunctivitis, 32% had nasolacrimal duct obstruction, blepharitis, chronic conjunctivitis and lid abscess. The remaining 8% had other ocular disorders. The isolated organisms were Haemophillus spp. [25%], coagulase negative Staphylococci [17%], Pneurmococci [10%], Pseudomonas aeruginosa [3%] and gram-negative bacilli [2%]. The sensitivity to lomefloxacin, chloramphenicol and ciprofloxacin were 94%, 96% and 95% respectively, Conclusion Topical lomefloxacin 0.3% is an effective antibacterial agent in the eradication of infection of the ocular surface. It has a wide range of efficacy against both gram-positive and gram-negative bacteria