Anaesthetic and surgical considerations of hepatotoxic effects of organophosphorous pesticides pollution on human and rabbit's liver

ABSTRACT

This work included clinical and experimental study to clarify the toxic effects of organophosphorous compounds [OPC]. The clinical work was done on 20 adult male patients known to be in contact with OPC passively or actively and scheduled for elective cholecystectomy under general anesthesia. Preoperative, operative and postoperative serum hepatic transaminase, alkaline phosphates, bilirubin and liver biopsy were studied. The experimental work included 24 rabbits allowed to inhale airline, rosepher and their mixture for five hours daily for seven successive days. Serum liver transaminase, alkaline phosphatase, bilirubin and liver biopsy were studied to clarify the histopathologic effects of OPC. This study proved that serum hepatic transaminase and alkaline phosphatase showed higher level than base level after anesthesia and postoperatively in clinical work. Liver biopsy revealed mild to moderate histopathologic changes in the form of fatty infiltration associated with focal steatosis. However, the experimental study showed marked and significant higher levels of serum hepatic transaminase and reduction of alkaline phosphatase level. Liver biopsy showed marked ballooning degenerative massive venous congestion and marked lymphatic infiltration