Coagulation inhibitors in patients with liver diseases

ABSTRACT

This study included twenty patients with acute viral hepatitis, forty patients with liver cirrhosis and twenty healthy controls matched for age and sex. It was found that the mean values of protein C were significantly low in patients with acute hepatitis and liver cirrhosis compared with controls. The mean values of AT III were significantly low in patients with acute hepatitis and liver cirrhosis compared with controls. There was no significant difference in the mean values of protein C and AT III between the group of acute hepatitis and the group of the liver cirrhosis. The level of protein C and AT III were significantly decreased with increased severity of liver cirrhosis. The mean values of FDP were significantly elevated in patients with liver cirrhosis compared with controls. A significant negative correlation was found between levels of both protein C and AT III with prothrombin time in patients with liver cirrhosis and acute hepatitis