Does intrauterine insemination in Saudi female cause production of antisperm antibodies?

ABSTRACT

To determine the possibility of inducing antisperm antibodies in patients undergoing intrauterine insemination with motile sperms from the husband. Clinico-immunological prospective study. King Abdulaziz University Hospital. Fifty patients undergoing Intrauterine Insemination [IUI], were tested for developing antisperm antibodies using agglutination test, complement mediated immobilization test, and immunoglobin specific indirect immunobead assay. Incidence and type of antisperms antibodies. Forty seven out of 50 patients remained negative for antisperm antibodies after 2-6 cycles of IUI. Detection of antisperm antibodies after IUI was evident in 3 patients [6 percent]. Intrauterine insemination does not appear to cause a significant or lasting immune response