study of P53 protein expression in cutaneous T-cell lymphoma

ABSTRACT

This study aimed to highlight the role of p53 mutations in development and progress of primary cutaneous lymphoma. Cutaneous biopsies of 15 consented patients with primary cutaneous T-cell lymphoma and five normal consented volunteers have been analyzed for p53 immunoreactivity using p53 monoclonal antibodies. The results showed a significant positive correlation between intensity of CD4 monoclonal antibody staining with both nuclear and cytoplasmic p53 overexpression. Accordingly, p53 overexpression may play a role in etiopathogenesis and prognosis of cutaneous T- cell lymphoma. Thus, it may be used as a prognostic marker as well as a monitor of therapeutic response