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level of tumour necrosis factor-alpha in subjects exposed to asbestos
Egyptian Journal of Occupational Medicine. 2000; 24 (1): 19-26
en Inglés | IMEMR | ID: emr-53644
ABSTRACT
The objective of the study is to evaluate the role of tumour necrosis factor Alpha [TNF-alpha] a in the pathogenesis of interstitial pulmonary fibrosis caused by occupational exposure to asbestos fibres by comparing its serum level in exposed versus non-exposed subjects. Twenty workers exposed to asbestos were chosen by simple random sampling and compared to a similar number of controls [unexposed to asbestos]. Both groups were subjected to history taking, clinical examination. TNF-alpha was measured in serum and correlated with possible relevant factors. Data analysis was done by SPSS computer based program. The study showed a significant increase in the level of TNF-alpha in the exposed group as compared to the controls. No correlation was found in the exposed group between the serum TNF-alpha level and respiratory symptoms, signs or disability nor with medical history. Further studies are needed to assess the use of serum TNF-alpha as an early predictor of susceptibility to the effect of asbestos. It could predict those more prone to develop asbestos-induced pulmonary injury. Anti-TNF should be assessed as a possible prevention or treatment for asbestos-induced lung injury
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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Sistema Respiratorio / Signos y Síntomas / Fumar / Exposición Profesional / Enfermedades Pulmonares Intersticiales / Factores de Necrosis Tumoral Límite: Humanos / Masculino Idioma: Inglés Revista: Egypt. J. Occup. Med. Año: 2000

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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Sistema Respiratorio / Signos y Síntomas / Fumar / Exposición Profesional / Enfermedades Pulmonares Intersticiales / Factores de Necrosis Tumoral Límite: Humanos / Masculino Idioma: Inglés Revista: Egypt. J. Occup. Med. Año: 2000