level of tumour necrosis factor-alpha in subjects exposed to asbestos

ABSTRACT

The objective of the study is to evaluate the role of tumour necrosis factor Alpha [TNF-alpha] a in the pathogenesis of interstitial pulmonary fibrosis caused by occupational exposure to asbestos fibres by comparing its serum level in exposed versus non-exposed subjects. Twenty workers exposed to asbestos were chosen by simple random sampling and compared to a similar number of controls [unexposed to asbestos]. Both groups were subjected to history taking, clinical examination. TNF-alpha was measured in serum and correlated with possible relevant factors. Data analysis was done by SPSS computer based program. The study showed a significant increase in the level of TNF-alpha in the exposed group as compared to the controls. No correlation was found in the exposed group between the serum TNF-alpha level and respiratory symptoms, signs or disability nor with medical history. Further studies are needed to assess the use of serum TNF-alpha as an early predictor of susceptibility to the effect of asbestos. It could predict those more prone to develop asbestos-induced pulmonary injury. Anti-TNF should be assessed as a possible prevention or treatment for asbestos-induced lung injury