Formulation and evaluation of sulindac capsules
Journal of Drug Research of Egypt. 2000; 23 (182): 91-104
en Inglés
| IMEMR
| ID: emr-54055
ABSTRACT
Sulindac, a non-steroidal anti-inflammatory drug [NSAID], was introduced in this work as capsules. Drug excipient interaction study applying DSC and TLC proved the sulindac compatibility with lactose as filler, primojel as disintegrant and magnesium stearate as lubricant. Such excipients were combined in different proportions according to 23 factorial design that helped in studying the effect of each adjuvant in the presence of other ones. The prepared capsules were checked for drug content and its uniformity that was conformed to the pharmaceutical standards. The formulated capsules were evaluated according to their dissolution profiles, disintegration time, bulk density, flowability and compressibility. The results were statistically evaluated according to Yate's analysis of variance
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Ratas
/
Cápsulas
/
Química Farmacéutica
/
Evaluación de Medicamentos
/
Ratones
Límite:
Animales
Idioma:
Inglés
Revista:
J. Drug Res. Egypt
Año:
2000
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