Acute graft dysfunction due to pyelonephritis, value and safety of graft biopsy

ABSTRACT

Objectives. To assess the value and safety of graft biopsy in patients who develop graft dysfunction due to pyelonephritis. Methods. Data analysis of all the patients with graft dysfunction and diagnosis of pyelonephritis was made on graft biopsy. During one year period six patients developed graft dysfunction due to pyelonephritis, all of these patients had an episose of acute cellular rejection in early post transplant period and received pulse steroid, while two in addition received ATG. Graft dysfunction when associated with UTI recovered within 4-6 weeks of antibiotic therapy. Graft biopsy is safe and histological diagnosis of pyelonephritis can save a patient from risk of anti rejection therapy given blindly in cases of graft dysfunction