Cefotaxime versus conventional antityphoid therapy for salmonella SPP. recently isolated in Basrah province, south Iraq: an in vitro study

ABSTRACT

to study the resistance patterns and in vitro activity of cefotaxime and 6 other antibiotics in 172 clinical isolates of Salmonella spp. Material and 172 isolates of Salmonella spp. recovered from blood, stool, or urine specimens were submitted to sensitivity studies. Antibiotic sensitivity testing was performed using the Kirby-Bauer disk diffusion method. apart from gentamicin [resistance rate = 10.26%], cefotaxime was the most effective drug against Salmonella isolates with a resistance rate of 12.79%. The highest rate of drug resistance was encountered for chloramphenicol [51.16%], followed by tetracycline [48.78%], and amoxicillin [43.02%]. The predominant sensitivity pattern was Amp[s] Amox[s] Chlor[s] CTX[s] [37.2%]. Only 6 of the 172 isolates were resistant to 4 drugs viz. Amp[r] Amox[r] Chlor[r] CTX[r]. solitary resistance to cefotaxime alone was observed in two cases only. 1.2%. the changing pattern in the Salmonella antibiogram is seen in this in vitro study; cefotaxime might serve as first therapy. The need for clinical studies is reemphasized