Molecular identity of major cross-reactive adult antigens in Fasciola gigantica, Toxocara vitulorum and Monieza expansa

ABSTRACT

Cross reactivity between Fasciola gigantica, Toxocara vitulorum and Moniezia expansa, whole worm extracts was proved by ELISA. Intense cross-reaction was observed between F. gigantica and M. expansa rather than between each of them and T. vitulorum. As judged by immunoblot, the cross-reactive antigens in F. gigantica which recognized by T. vitulorum antisera was 109 kD, while this component in addition to another one of 52 kD were detected by M. Expansa sera in the same extract. Furthermore, T. vitulorum antigen which cross-reacted with F. gigantica, was 133 kD and with M. expansa was 143 kD. Antigens responsible for cross-reactivity in M. expansa were 130 kD and 210 kD to T. vitulorum and F. Gigantica, respectively