Trace elements anti oxidant and streptozotocin-induced diabetes in rats

ABSTRACT

This study was conducted to delineate the possible therapeutic potential of chromium, lithium or selenium on glucose homeostasis, lipid profile and oxidative stress profile in streptozotocin-induced diabetes in rats treated by a subtherapeutic single daily dose of gliclazide [2mg/kg/day]. Therapeutic dose of gliclazide [10 mg/kg/day] produced a significant correction of the observed changes in serum glucose, serum C-peptide, liver glycogen, liver cholesterol, liver glutathione, lipid profile and oxidative stress parameters. On the other hand, subtherapeutic dose gliclazide [2 mg/kg/day] caused a significant decrease in serum glucose level, while the other studied parameters did not change. Lithium or selenium supplementation corrected the observed changes in liver glycogen, liver glutathione, lipid profile and the different oxidative stress parameters including glutathione peroxidase activity