Effect of intrathecal verapamil on the anterior horn cells of adult albino rat's spinal cord: Experimental and microscopical study

ABSTRACT

In the present study, 15 adult albino rats were used and divided into three equal groups. The first group was considered a control group, while animals in the second group were injected with a single intrathecal dose of verapamil. Animals of the third group were injected with three successive doses of the drug. The results have shown no changes in either cell character or nuclear diameter after single dose of intrathecal verapamil. Also, no changes in nucleic acid contents were detected. Repeated intrathecal injections led to a decrease in the diameters of both the cell and its nuclei as well as nucleus/cytoplasmic ratio [N/C ratio]. The nucleic acid contents were still also not affected