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Effects of trichloroacetate, water chlorination by-product, on liver peroxisomes and antioxidant status in rats and mice
Scientific Journal of Al-Azhar Medical Faculty [Girls] [The]. 2000; 21 (2): 631-648
en Inglés | IMEMR | ID: emr-55548
ABSTRACT
Seven groups of each of male Fischer 344 rats and B6C3F1 mice were provided with drinking water containing distilled water 0.05 g/L trichloroacetate [TCA], 0.5 g/L TCA, 1.0 g/L TCA, 4.5 g/L TCA; distilled water + vitamin E and 4.5 g/L TCA + vitamin E, respectively, for 30 days. Liver palmitoyl Co-A oxidase [PCOA] and glycolate oxidase were estimated as peroxisomal enzymes. In addition, the liver content of water-soluble antioxidants, antioxidant enzymes and alpha- tocopherol were measured. These results demonstrated that the mouse is more sensitive than the rat with respect to the enhancement of liver peroxisome proliferation by TCA. A condition of oxidative stress produced by TCA exposure in drinking water was conducted. The possible role of oxidative damage in the hepatic carcinogenicity of TCA may be involved
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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Ratas Endogámicas F344 / Ácido Tricloroacético / Tricloroetileno / Vitamina E / Agua / Peroxisomas / Ratones / Antioxidantes Límite: Animales Idioma: Inglés Revista: Sci. J. Al-Azhar Med. Fac. [Girls] Año: 2000

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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Ratas Endogámicas F344 / Ácido Tricloroacético / Tricloroetileno / Vitamina E / Agua / Peroxisomas / Ratones / Antioxidantes Límite: Animales Idioma: Inglés Revista: Sci. J. Al-Azhar Med. Fac. [Girls] Año: 2000