Plasma homocysteine and endothelin-I in patients with type-I [IDDM] diabetes

ABSTRACT

This study was performed on 40 type I diabetes [IDDM] patients with complications [nephropathy and retinopathy], 20 IDDM patients without complications and 20 age and sex matched healthy control subjects. IDDM patients with complications had significantly higher fasting total homocysteine [tHCY] and endothlin-1 [ET-1] plasma levels than the other two groups. In diabetic patients without complications, plasma tHCY had a slight increase than the control subjects, while plasma level of ET-1 was significantly higher than the control subjects. tHCY plasma level was correlated with albumin excretion rate [AER], serum creatinine and ET-1 glycated hemoglobin [HbA1c], but it was not correlated with the duration of diabetes mellitus, serum lipids and age of the patients