Evaluation of TNF alpha and ILI beta cytokines in hepatocellular carcinoma [HCC] cases

ABSTRACT

The aim of this study was to estimate the levels of TNF alpha and ILI beta cytokines in 35 HCC patients and ten healthy controls in order to determine the implication of these cytokines in the pathogenesis of such conditions and subsequently establishing a therapeutic scheme. An estimation of serum TNF alpha and ILI beta levels was done using ELISA technique. The results showed a statistical significant elevation of TNF alpha and ILI beta levels in HCC patients when compared with the control group with a positive correlation between these two cytokines. It was recommended to use TNF alpha mutated protein by altering amino acid sequences to modulate affinities to TNF alpha receptors to be active against HCC without severe toxicities