Clinical efficacy of oral clonidine in anaesthetic practice

ABSTRACT

This study was done on 40 adult patients ASA physical status I and II subjected to an elective surgery. The effects of oral clonidine were investigated during general and spinal anesthesia. It was found that oral administration of clonidine as a premedication had significantly more sedation and less anxiety in patients undergoing general or spinal anesthesia. It also had advantageous hemodynamic effects resulted in a significant reduction of HR and ABP [SBP, DBP, MBP] in preinduction, postinduction and intra-operative measurement. Clonidine premedication attenuated the cardiovascular response to the stress of laryngoscopy and endotracheal intubation