Leucemies aigues myeloblastiques de l'enfant. A propos de 21 cas

ABSTRACT

Between 1989 and 1996,21 cases with acute non lymphoblastic leukemia [11 males and 10 females] were diagnosed in our institution. Median age was 9 years [range, 2-15 years]. leukocyte count was more than 50.109/1 in 47% of cases. According to the French-American-British [FAB] criteria, 7 cases were classified M 1, 10 cases were classified M2, 1 classified M4Eo and 3 classified M5. All patients were treated with" 7+3 " protocol and complete remission was achieved in 17 cases [80%], 2 cases [10%] Failed to respond and 2 [10%] died during induction. Relapse was observed in 15 cases. The 3-year survival rate was 20% and the relapse-free survival rate was 12% confirming the worse prognosis of this leukemia when treated with standard chemotherapy