Effect of percutaneous translumminal coronrary angioplasty on endothelin level

ABSTRACT

the endothelins are a family of three isopeptides that are extremely potent vasoconstrictors both in vivo and in vitro. The development of sensitive assays has allowed the measurement of the low concentrations of endothelin in plasma. A preliminary study on the release of ET-1 after percutaneous transluminal coronary angioplasty [PTCA] provided neither a control group nor a time course after PCTA. This study was designed to evaluate the time course of ET-1 release in the coronary vascular bed of patients with ischemic heart disease undergoing PTCA. Fifteen patients in sinus rhythm with ischemic heart disease [Canadian Cardiovascular Association class II to III] with mean age [45 +/- 3.5 years] underwent first time coronary angiography, which showed one or more vessel disease [stenosis ranging from 70% to 90%]. ET immuno-reactivity was measured in paried samples of coronary venous blood and peripheral venous blood. The samples were drawn before PTCA and just after the final ballon inflation 10, 30 min PTCA from a peripheral vein. plasma endothelin level in the coronary sinus was significantly increased from 4.2 +/- 1.2 pg / ml to 11.5 +/- 1.9 pg / ml after PTCA [P=0.0001]. these results suggest that the increase of plasma endothelin level in the coronary sinus may be associated with the coronary endothelial injury by PTCA