Effects of tetrachloroethylene and vitamin E on renal parenchyma of albino rats

ABSTRACT

To evaluate the role of vitamin 'E' against tetrachloroethylene induced nephropathies. Fifty adult albino rats of either sex were divided into five equal groups; normal control [A], sesame oil control [A2], tetrachloroethylene treated group [B], experimental group [C] and vitamin 'E' control [D], In group C vitamin 'E' [10 mg/animal] was injected simultaneously with tetrachloroethylene [3mg/kg] for 15 days. On completion of treatment all the animals were sacrificed. There kindneys removed, processed for paraffin embedding and stained with H and E, PAS and Alcian Blue. Simultaneous administration of vitamin 'E' and tetrachloroethylene showed unaltered morphology of renal cortical parenchyma, comparable with that of group A1, A2 and D kidneys, except slight proximal tubular dilatation. Tetrachloroethlene induced nephropathy may partially be prevented by simultaneous administration with vitamin 'E' in albino rats