Enhancement of dissolution and bioavailability of firoxicam via solid dispersion with phospholipids

ABSTRACT

In this work physical mixtures [PMs] and coprecipitates [COPPTs] of piroxicam [PIR] with each of L-alpha-dimyristoylphosphatidylcholine [DPPC] and L-alpha-distearoylphosphatidycholine [DSPC] in ratios of 201, 101 and 51 [drug-to-phospholipids w/w] were prepared. The effect of the method of preparation, the type of phospholipids [PL] and the drug-to-PL w/w ratios on the rate and extent of dissolution of PIR was investigated. The effect of the previously mentioned factors on the dissolution efficiency [DE%] was analyzed using two-way analysis of variance [ANOVA]. The most significant effect on the dissolution rate and extent was due to the method of preparation followed by the drug-to-PL ratio and finally the PL type. All PIR-PL systems improved the dissolution rate of piroxicam, but coprecipitates of 51 w/w ratio showed the superior effect on the drug dissolution profile