Determination of paracetamol bromopotentio-metrically using silver amalgam and bromide ion-selective electrode

ABSTRACT

A study of the oxidation of paracetamol with bromine in acetate buffer media has been carried out using potentio bromometric techniques. The different variables such as ratio of the reactants, temperature, pH and time affecting the microdetermination of paracetamol were investigated. The optimum conditions obtained at [Br[2]] / [p-AAP] = 3.0, T = 303K, pH = 4.0 and t = 5 - 10 min, permit the quantitative determination of paracetamol in the concentration range of 0.113 to 13.61 mg using silver amalgam electrode or in the concentration range of 143 to 638 micro g ml[-1] using bromide ion-selective electrode. Application of the proposed techniques for rapid, simple and direct determination of paracetamol in ten different pharmaceutical preparations was demonstrated