Study of plasma Amylin concentration in patients with insulin dependent diabetes mellitus

Twenty insulin dependent diabetes mellitus patients and twenty healthy control subjects were included in this study. Fasting plasma amylin level was done. The mean of amylin level in patients was [1.61 +/- 1.2] ng/ml and the mean of amylin level in controls was [6.21 +/- 2.0 ng/ml]. The amylin level was significantly lower in patient with type I diabetes than control [P< 0.001].The decrease of amylin level in IDDM patients together with its apparent insulin antagonistic action raised the speculations about its possible role in the counter regulation of hypoglycemia in this disease