Study of thyroid hormones concentrations in egyptian patients with chronic active hepatitis postvirus C Infection

ABSTRACT

Serum total T3 [TT3], serum free T3 [FT3], serum total T4 [TT4], serum free T4 [FT4] and serum thyroid stimulating hormone [TSH] were assessed by radio-immunoassay in [30] Egyptian patients with chronic active hepatitis [CAH] post -virus C [group I] and [30] normal healthy subjects [group II]. Our results showed highly significant decrease [P<0.01] of TT3 and FT3 concentrations in the diseased group as compared to normal control group Also, our findings showed highly significant increase [P<0.01] of TT4, FT4 and TSH concentrations in cases with CAH post-virus C when compared to normal control group. In present work, upon doing matrix correlation, the results showed significant moderate negative correlations were observed between FT3 concentration [pg /ml], and SGOT [lu /L] and SGPT [lu /L] while non significant weak correlations were found between FT3 concentration [pg /ml] and total bilirubin [mg /dl] and prothrombin activity. Also, the findings showed significant moderate positive correlations were detected between FT4 concentration [pg / ml] and SGOT [lu /L] and SGPT [lu /L] while non significant weak correlations were observed between FT4 concentration [pg / ml] and total bilirubin [mg / dl] and prothrombin activity [seconds]. Lastly, there was noted significant moderate negative correlation between total serum protein [gm /dl] and FT3 [pg/ml] concentrations In conclusion, thyroid function affection may associated with CAH post virus C and this affection is directly proportional to the degree of hepatic damage