Effect of metformin treatment in ovulatory and pregnancy rates of patients suffering from polycystic ovarian syndrome [PCOS] with clomiphene citrate [CC] resistance

ABSTRACT

A double blind prospective study was planned to determine the effect of additional metformin treatment in. The ovulation and pregnancy rates among infertile anovular women who are suffering from polycystic ovarian syndrome [PCOS] and who are resistant to clomiphene citrate [CC] treatment alone. Prince Sultan military hospital, Taief, Saudi Arabia. This study included 25 infertile anovular patients with PCOS who were resistant to induction by CC. Participants received placebo or metformin, 500 mg three times daily, for 7 weeks. Information on reproductive steroids, gonadotropin, and oral glucose tolerance testing was obtained at baseline and after treatment. CC treatment was begun at 50 mg daily for 5 days. Serum Progesterone [P] level> 4mg/ml were considered to indicate ovulation in addition to ultrasound monitoring. With anovulation, the daily CC dose was increased by 50 mg for the next. Patients completed the study when they had six cycles, became pregnant, or experienced anovulation while receiving 150 mg of CC. In the metformin and placebo groups, 9 of 12 participants [75%] and 4 of 15 participants [27%] ovulated, and 6 of 11 participants [55%] and 1 of 14 participants [7%] conceived, respectively. Comparisons between the groups were significant. The use of metformin significantly increased the ovulation rate and pregnancy rate in anovulatory women. With PCOS who are resistant to CC