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Serum cystatin-C: a better predictor of decreased creatinine clearance than serum creatinine in cancer patients on cisplatin
Annals Abbassi Shaheed Hospital and Karachi Medical and Dental College. 2002; 7: 278-85
en Inglés | IMEMR | ID: emr-58893
ABSTRACT
To observe the effects of acute deterioration in GFR, induced by cisplatin, on the levels of serum creatinine and cystatin C and to correlate the level of serum creatinine and cystatin C among cancer patients and the controls.

Design:

It is a comparative study carried out in the Department of physiology, Basic Medical Sciences Institute, Jinnah Postgraduate medical Centre, Karachi.

Subjects:

Seventy subjects were included in the study. Group I comprising of cancer patients with GFR greater than 80 ml/min/1.73m2 and group II comprising of cancer patients with GFR less than 80 ml/min/1.73m2. Estimations of serum creatinine, urinary creatinine and cystatin C in all subjects were done twice, first before the start of chemotherapy with cisplatin and second before the start of second cycle.

Result:

A highly significant correlation was found between the reciprocals of the levels of cystatin C and creatinine clearance as compared to a less significant Pvalue, which was found between the reciprocals of the levels of creatinine and creatinine clearance. In conclusion, the results of this study emphasizes that serum cystatin C is a promising endogenous marker of GFR, and it might be of particular interest in patients with slightly decreased renal functions
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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Cisplatino / Creatinina / Tasa de Filtración Glomerular / Neoplasias Límite: Humanos Idioma: Inglés Revista: Ann. Abbassi Shaheed Hosp. Karachi Med. Dent. Coll. Año: 2002

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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Cisplatino / Creatinina / Tasa de Filtración Glomerular / Neoplasias Límite: Humanos Idioma: Inglés Revista: Ann. Abbassi Shaheed Hosp. Karachi Med. Dent. Coll. Año: 2002