Serum cystatin-C: a better predictor of decreased creatinine clearance than serum creatinine in cancer patients on cisplatin

ABSTRACT

To observe the effects of acute deterioration in GFR, induced by cisplatin, on the levels of serum creatinine and cystatin C and to correlate the level of serum creatinine and cystatin C among cancer patients and the controls. Design: It is a comparative study carried out in the Department of physiology, Basic Medical Sciences Institute, Jinnah Postgraduate medical Centre, Karachi. Subjects: Seventy subjects were included in the study. Group I comprising of cancer patients with GFR greater than 80 ml/min/1.73m2 and group II comprising of cancer patients with GFR less than 80 ml/min/1.73m2. Estimations of serum creatinine, urinary creatinine and cystatin C in all subjects were done twice, first before the start of chemotherapy with cisplatin and second before the start of second cycle. Result: A highly significant correlation was found between the reciprocals of the levels of cystatin C and creatinine clearance as compared to a less significant Pvalue, which was found between the reciprocals of the levels of creatinine and creatinine clearance. In conclusion, the results of this study emphasizes that serum cystatin C is a promising endogenous marker of GFR, and it might be of particular interest in patients with slightly decreased renal functions