Synthesis, molecular modeling and anticancer activity of certain acridine derivatives
Egyptian Journal of Pharmaceutical Sciences. 2002; 43 (1-2): 73-103
en Inglés
| IMEMR
| ID: emr-59203
ABSTRACT
Eight series of new acridine derivatives of anticipated antitumor activity were synthesized. The first and second series belong to 9- anilinoacridines. The third series belongs to 9-anilinoacridine-4- ylmethylamino benzenesulfonamides. The fourth one composes of acridone methylamino benzenesulfonamides. The fifth and sixth series comprise of 9-anilinoacridine-4-acetamide derivatives. The seventh series is the derivatives of 9-oxo-9,10-dihydroacridine-4-acetamide. The last series includes 9-oxo-9,10-dihydroacridine-2-sulfonamides. Also, one known final compound has been synthesized following a new pathway. The rationale behind the synthesis of these compounds, their methods of synthesis as well as their antitumor activity, were discussed
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Bioensayo
/
Modelos Moleculares
/
Antineoplásicos
Idioma:
Inglés
Revista:
Egypt. J. Pharm. Sci.
Año:
2002
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