Anti - nociceptive effect of the fruit essential oil of cuminum cyminum L. in rat
IBJ-Iranian Biomedical Journal. 2002; 6 (4): 141-5
en Inglés
| IMEMR
| ID: emr-59451
ABSTRACT
Cuminum cyminum Linn. [Umbelliferae] is a plant, which has been used as a toothache remedy in folk medicine of Iran. In this study, the potential anti-nociceptive and anti-inflammatory activities of the fruit essential oil of C. cyminum has been evaluated in chemical [formalin test] and thermal [tail-flick test] models of nociception and formalin model of acute inflammation in rats and mice. The essential oil at the doses ranging between 0.0125 and 0.20 ml/kg exhibited a significant and dose-dependent analgesic effect in the model of chronic and inflammatory pain. However, the essential oil was devoid of anti-inflammatory activity. Moreover, the essential oil had no analgesic effect in tail flick test as a model of acute pain. The LD50 value of 0.59 ml/kg was obtained for the essential oil. This low toxicity of the essential oil makes it worthy for further studies
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Ratas
/
Aceites Volátiles
/
Extractos Vegetales
/
Frutas
/
Analgésicos
/
Ratones
Límite:
Animales
Idioma:
Inglés
Revista:
Iran. Biomed. J.
Año:
2002
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