Study of risk factors for cervical cancer a case-controlled study in Isfahan-Iran

ABSTRACT

Cervical cancer is the third most common malignancy of the female genital tract. The main objective of this study was to determine the risk factors for cervical cancer. Method: This was a case-control study. From a total sample of 263 women, 87 patients with diagnoses of invasive cervical cancer comprised the case group arid another 176 healthy females were in the control group. The location of research was at two oncology referral hospitals of 1sf ahan Amin and Seyed Al-Shohada. Multiple logistic regression modules were used to analyze the data by SPSS-9 software. The results of the study showed that cervical cancer is related to age at first marriage [OR=5, 95% CI 1.5-16.6; P=O.008], number of deliveries [OR=3.3, 95% CI 1.2-8.8; P=O.02] and type of oral contraceptive used. In connection with duration of using oral contraceptives, the results showed that in those women who used oral contraceptives for a period of >5 years [OR=3.3, P=O.008], the mean number of sexual intercourses per week at four decades of marriage life was more in the case group compared with the control group [P=O.0001]. Socioeconomic status differences were not significant. False negative Pap smear test results were about 15.5%. This study identified some risk factors related to the incidence of cervical cancer i.e. younger age at the first coitus, number of intercourses per week, number of deliveries and duration of oral contraceptive use