Serum and salivary IgA in mumps

The material comprised 20 children suffering from mumps and 10 healthy children who served as the control group in addition to thorough clinical examination, determination of serum and salivary IgA levels were done These tests were done during the 1st or 2nd day of appearance of the swelling and 2-4 weeks later One patient was tested after 9 months. The highest levels of serum IgA could be detected in the early stages of clinical disease then it gradually decreased, but we can detect high levels up to 9 months. Mumps infection caused decreased production of S. IgA in the early stages of clinical disease. High levels of S IgA could be detected 2-4 weeks later then these levels decreased gradually. Following exposure to mumps virus, there is replication of the virus in the mucosa of the portal of entery. Which will stimulate the production of S IgA after a short period of depression This is followed by a stage of viraemia which Stimulates increased production of serum immunoglobulins including IgA which prevents replication of the virus In peripheral tissues. S IgA establishes immunity by preventing colonization of mucous menbrane and in this case immunity is not associated with the carrier state