Acute poisoning by cholinesterase inhibitor insecticides: Effect on myocardial, hepatic and pancreatic functions in humans

ABSTRACT

The aim of the present work was to study patients with cholinesterase inhibitor insecticides intoxication as regards clinical manifestations, myocardial, hepatic and pancreatic affection with their laboratory investigations. The study was carried out on fifty consecutive patients with acute intoxication by ChEII admitted to Alexandria Poison Center and critical medicine department at Alexandria Main university hospital, Alexandria, Egypt. A control group of fifteen healthy subjects were randomly chosen. They were clinically free, not exposed to ChEII and of the same age group and sex as the patients. All patients were examined as regards; history and circumstantial evidence. Clinical examination and electrocardiogram [ECG] were done to all patients on admission. Also, laboratory investigation and determination of serum cholinesterase enzyme activity, serum glucose, trypsin, AST and ALT activity were carried out