Prenatal Diagnosis and assessment of fetal malformations by three dimensional ultrasonography at Galaa teaching hospital in Egypt

ABSTRACT

This study included 1000 pregnant women at high risk pregnancy of fetal anomalies. A detailed three-dimensional ultrasonography [3-DUS] examination was performed in each pregnancy between 11-22 weeks of gestation. A neonatal evaluation or pathological examination was made to confirm the prenatal findings. The results showed that the total prevalence of fetal abnormalities in the sample was 4.9%. The overall sensitivity in detecting fetuses with congenital abnormalities was 81.6%. The sensitivity per system was 100% for central nervous system [CNS], 75% for genetic syndromes and 50% for cardiovascular system [CVS] and Down syndrome. Some anomalies like hypospadias were not detected prenatally by sonographic examination. In 12 cases, pregnancy was terminated due to lethal congenital anomalies [anencephaly and bilateral renal agenesis]