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Immunohistochemical determination of HER-2 / new overexpression in invasive ductal carcinoma of breast with cervical nodal metastasis
Pakistan Journal of Otolaryngology-Head and Neck Surgery. 2002; 18 (2): 29-31
en Inglés | IMEMR | ID: emr-60427
ABSTRACT
This study was designed to determine the frequency of HER-2/neu overexpression, in invasive ductal carcinoma of breast and correlate it with various standard prognostic parameters. This study was performed on formalin fixed paraf n embedded blocks of 72 diagnosed cases of invasive ductal carcinoma of breast. The blocks were retrieved and the staining was done to see the HER-2/neu overexpression. Sections containing > 50% of tumour cells showing intense circumferential cell membrane staining scored as positive. The HER-2/neu overexpression was seen in 31% of cases. A significant relationship [P<0.05] was found between HER-2/neu overexpression and lymphnode status and size of the tumour. The overexpressivity of HER-2/neu oncoprotein suggests that Herceptin can be used as therapeutic measure on these cases
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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Neoplasias de la Mama / Inmunohistoquímica / Carcinoma Ductal de Mama / Receptor ErbB-2 / Ganglios Linfáticos / Cuello / Metástasis de la Neoplasia Límite: Femenino / Humanos Idioma: Inglés Revista: Pak. J. Otolaryngol.-Head Neck Surg. Año: 2002

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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Neoplasias de la Mama / Inmunohistoquímica / Carcinoma Ductal de Mama / Receptor ErbB-2 / Ganglios Linfáticos / Cuello / Metástasis de la Neoplasia Límite: Femenino / Humanos Idioma: Inglés Revista: Pak. J. Otolaryngol.-Head Neck Surg. Año: 2002