Acid phosphatase positive Tlymphoblastic leukaemia [T-ALL] in Pakistani children
JPMA-Journal of Pakistan Medical Association. 1985; 35 (1): 6-9
en Inglés
| IMEMR
| ID: emr-6097
ABSTRACT
T-Lymphoblastic leukaemia [T-ALL] appears to be associated with factors known to be of bad prognosis in Acute lymphocytic leukaemia [ALL]. Acid phosphatase reaction [AP], a specific non-immunological cytochemical marker for T-ALL was performed on peripheral blood and bone marrow slides of fifty children with ALL to assess the frequency of T-ALL in our population. Myeloperoxidase [P] and Alpha-Napthyl Esterase [NASA] were performed to exclude Acute myelocytic and Monoblastic leukaemia. A strong localised AP reaction in more than fifty percent of the blasts was taken as positive for T-ALL. Of the fifty cases studied 32% showed strong AP positivity in majority of the cells. These were negative for both P and NASA and showed varied Periodic Acid Schiff [P.A.S.] positivity. This high frequency of T-ALL in our series may explain the poor response to therapy and high relapse rates observed in our population
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Fosfatasa Ácida
/
Niño
Idioma:
Inglés
Revista:
J. Pak. Med. Assoc.
Año:
1985
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