Interpretation d'une hypertransaminasemie

ABSTRACT

Raised serum level of transaminases aspartate [aminotransferase and alanine aminotransferase] is a frequent situation in medical practice. It is considered as moderate when the level is under 10 times normal and as chronic when it lasts for more than 6 months. The most common etiologies for chronically elevated transaminases are alcohol use, viral hepatitis, liver steatosis, diabetis, obesity and medications. Many non invasive tests, including history, physical examination, blood tests [markers for hepatitis A AND B, muscular enzymes], and imaging procedures [abdominal ultrasonography] are usually done and lead to a correct diagnosis in 80% of patients. When the diagnosis cannot be determined non invasively a liver biopsy is recommended in order to make diagnosis, to evaluate the prognosis and to start an adapted treatment